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《决不妥协》是一部涉及经济犯罪、医疗纠纷、报复杀人的伦理剧：2006年2月12日夜里9时08分，医生张路（徐路饰）全力抢救一个叫小敏的受伤女患者，张路尽了最大努力，但小敏还是因为大出血而离开了这个世界。小敏的母亲杜丽（宋春丽饰）悲痛欲绝，对张路兴师问罪，认为是张路的失职导致女儿的离去。。Sheriff Sean Kilpatrick is a pacifist. Frank Brand is the leader of a band of killers. When their paths cross Kilpatrick is compelled to go against everything he has stood for to bring death to Brand and his gang. Through his hunt into Mexico he is challenged by a noble Mexican Sheriff interested only in carrying out the law - not vengeance.。